Multiple capillary haemangiomas in 4 month old-Glare at the rare.

Dr Vikas kapoor, Dr Shalini kapoor, Dr Jiji John,Dr Manish Tiwari.

Corresponding Author:- Dr Shalini kapoor Asstt professor, Department of periodontology SGT dental college.Indore


Haemangiomas are the most common tumors of infancy and are characterized by a proliferating and involuting phase. Haemangiomas occupy a gray zone between hamartomatous malformations and true neoplasm. Despite their self-limited course, infantile capillary hemangiomas can impair vital or sensory functions and cause cosmetic deformity. They are seen more commonly in whites than in blacks, more in females than in males in a ratio of 3: 1. The present article is a case report of clinical diagnosis of multiple capillary haemangiomas in four month old baby girl . The article also discusses about the brief review about the history, diagnosis, classification and treatment plan of multiple capillary haemangiomas.

Key words :Haemangiomas , Tumors, Infancy.


Vascular lesions are among the most common congenital and neonatal abnormalities. Haemangioma is a benign, localized tumor of the blood vessels. Most of the benign vascular lesions occurring in the head and neck region have a malformational, hamartomatousbasis1. They are frequently designated and regarded as tumors because of their usually localized nature and mass effect. The fact that they consistently lack chromosomal alterations, speaks against a true neoplastic nature2. Although clearly benign, over half of these cases are in head and neck region. They can also occur in the trunk or extremities.
Most hemangiomas are solitary; when multiple (with or without associated lesions in internal organs) or affecting a large segment of the body, the condition is known as multifocal angiomatosis. This occurs more commonly in whites than in blacks. They are characterized by a proliferating and involuting phase. Growth in early infancy, during the proliferative phase, is embodied by rapidly dividing endothelial cells forming syncytial masses; thickened, multilaminated basement membranes; and elevated mast cell concentrations. Proliferating-phase hemangiomas display a ten-fold increase in mast cell concentration.In the present
article we are discussing a case report of multiple haemangiomas on extremetries ,head and neck region and oral cavity . While this birthmark may be alarming in appearance, physicians generally counsel that it be left to disappear on its own, unless it is in the way of vision or blocking the nostrils3.
A capillary hemangioma (also known as an “Infantile hemangioma,‖ “Strawberry hemangioma”, and “Strawberry nevus”) is the most common variant of hemangioma which appears as a raised, red, lumpy area of flesh anywhere on the body, though 83% occur on the head or neck area4.Capillary hemangioma is a hamartoma—an abnormal, localized proliferation of vascular endothelial cells. One of the most common benign orbital tumors in children, capillary hemangioma affects up to 2 percent of all infants, with a female predilection (3:2 ratio). The incidence of eyelid and orbital hemangiomas is about one tenth that of systemic infantile hemangiomas, which occur in about 10 percent of all children by 1 year of age. Approximately one-third of capillary hemangiomas are apparent at birth, while the remaining two-thirds manifest by 6 months of age5.       

The present case is of a four month old baby girl with multiple capillary haemangiomas all over her body including oral cavity .The lesions were circumscribed, painless , red in color, raised with thin overlying skin and had spongy consistency. 

                                                                                       Figure 1 : Showing Multiple Haemangiomas on Face.

There was no gross abnormality detected. The first suspicion was of any internal malignancy or systemic vascular malformations. Investigations advised to the patient was  ultrasound , CT scan , MRI , Chest X-Ray and ophthalmic examination .Ultrasound abdomen did not reveal any vascular malformations, chest x-ray was normal and there was no abnormal vascularisation, Ophthalmic examination was normal too. There was no bruits heard . MRI is obtained to determine the extent of the lesions and it  did not showed ant systemic involvement The natural history of capillary hemangioma is an initial rapid growth phase, usually within the first six to nine months of life, followed by stabilization at around 12 to 15 months of life and then protracted involution over many years. As the lesion was Involuting & nonproliferative , so it was managed by observation and patient recall after 6 months.
First case of hemangioma was documented by Liston(1843) . Theory that hemangiomas are neoplasms was strongly supported by the study of Mulliken and GIowacki (1982). Later Douglas Marchuk (2001) in their study defined hemangioma as a benign tumor that exhibits an early and rapid proliferation phase during the first year of life, and is characterized by endothelial and pericytic hyperplasia, followed by a slower but steady involution phase that may last for years.
Age : The first intradermal hemangioma was identified by Edgerton M T, Heibert J M (1978) and they stated that it is frequently present at birth6. Walter, John Brahn (1979) reported that hemangiomas are usually present at birth or else appear soon afterwards.Thomas. Fitzpatrick (1987) reported that capillary hemangiomas are first noted shortly after birth7,8. Douglas Marchuk (2001) reported that hemangiomas are the most common tumors of any kind seen in infancy9.
Sex: Lister WA et al (1938) found that capillary hemangioma affected females slightly more than males10,11.                                                                    … Site: Kasabach, Merrit (1940) found that hemangiomas are benign vascular tumors that may occur in any tissue of the body. They said that skin is the structure, which is most commonly affected. JohnsonWC stated that cherry angiomas are very common and present as red papules on the trunk and upper limbs of middle aged and elderly adults. Jerome B Taxy et al (1979) found that hemangiomas of the soft tissues in infants and children are rapidly growing, particularly in the head and neck area12.  Infantile hemangiomas occur anywhere on the skin, but the head and neck is the most commonly affected, followed by the trunk and limbs. Hemangiomas may involve  mucous membranes of the oral and genital regions.
Clinical Features                                                                                                                                                                                                                                 ..Clinically capillary hemangioma may present as a cutaneous, subcutaneous or deep orbital lesion or a combination of the three. The superficial cutaneous lesion, or ―strawberry nevus,‖ is initially evident as a confluence of telangiectasias, which later progresses to a red, raised nodular lesion that blanches with pressure. The subcutaneous lesion typically has a bluepurple hue and a spongy consistency. The deeper orbital lesion may present with proptosis and globe displacement.On palpation oral mucosal hemangiomas are typically soft, moderately well circunscribed, painless masses that are red or blue in color13. However about one-third or more of the hemangiomas manifest in the new born nursery, as a premonitory vascular ―birthmark‖ – either as a tiny red papule, telangiectasia, pale nodule or pseudoecchymosis. Enzinger, Weiss (2001) were of the opinion that capillary hemangioma during the early stage resembles a common birth mark and is seen as a flat red lesion that intensifies in color when the infant cries or strains.. Capillary hemangioma appears as a redblue multinodular mass with a thin overlying skin14.   


  • Most common benign tumor in childhood.
  • Affects ~1:10 children
  • Responds to Propranolol
  • Rapid proliferation followed by involution
  • Increased in following populations:
  1. Primies.
  2. Multiple gestational babies.
  3. In vitro fertilization. 
  4. Caucasians. 
  5. Females. 
  6. GLUT-1 positive.

                                                                                             Table 1:  Clinical Features of Haemangioma.

  1. Imaging techniques15
    CT scans are useful in the investigations of hemangioma.
  2. MRI (magnetic resonance imaging) 
  3. Angiography 
  4. Panoramic Radiograph 
  5. Ultrasonography with color Doppler

    Hemangiomas are tumors identified by  rapid endothelial cell proliferation in early  infancy, followed by involution over time.  All other abnormalities are malformations  resulting from anomalous development of  vascular plexuses. The malformations have  a normal endothelial cell growth cycle that  affects the veins, the capillaries, or the  lymphatics and they do not involute. A  number of growth factors including vascular endothelial growth factor [VEGF], basic fibroblast growth factor [bFGF], transforming growth factor-beta  [TGF-beta] and interleukin 6 [lL6] have  been demonstrated as regulators of  angiogenesis. A number of cellular  markers have been outlined such as TIMP l, b FGF, proliferating cell nuclear antigen,  type IV collagenase and urokinase.  Hemangiomas of the oral cavity are not  common pathologic entities, but, among  hemangiomas, the head and neck are  common sites. Most hemangiomas  involute with time, but a certain small  percentage do not, which may present with  complications that require treatment.  To conclude hemangiomas pose  perplexing questions that will only be  answered as the events that initiate  hemangiogenesis are elucidated These are some of the questions that have to be  addressed in the future.

  1. Allen P WEnzinger F MHemangioma of skeletal muscle: an analysis of 89 cases. Cancer 1972; 29: 822

  2. Beth A DNancy B EIllona J FHemangiomas in children. N Engl J Med 1999; 341: 173181 

  3. Cohen A J, Youkey J R, Clagett G P, Huggins M, Nadalo L, d’Avis J C. Intramuscular hemangioma. JAMA 1983; 249: 2680–2
  4. Demir ZOktem FCelebioglu SRare case of intramasseteric cavernous hemangioma in a three-year-old boy: a diagnostic dilemma. Ann Otol Rhinol Laryngol 2004; 113(6)4558
  5. Finn M CGlowacki JMulliken J BCongenital vascular lesions: clinical application of a new classification. J Pediatr Surg 1983; 18: 894900 ]
  6. Greinwald J H, JrBurke D KBonthius D JBauman N MSmith R JAn update on treatment of hemangiomas in children with interferon Alfa-2a. Arch Otolaryngo Head Neck Surg 1999; 125: 217
  7. Hasan QTan S TGush JDavis P FAltered mitochondrialcytochrome b gene expression during the regression of hemangioma. Plast Reconstr Surg 2001; 108(6)14716
  8. Hochman MVural ESuen JWaner MContemporary management of vascular lesions of the head and neck. Curr Opin Otolaryngol Head Neck Surg 1999; 7: 161
  9. Murphey M DFairbairn K JParman L MBaxter K GParsa M BSmith W SMusc uloskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics 1995; 15: 893917
  10. O’Donnell T M PDevitt A TKutty SFogarty E ERecurrent congenital hemipericytoma in a child. J Bone Joint Surg (Br) 2001; 83: 26972
  11. Shafranov V VButorina A NBorkhunova E NTreatment of hemangiomas in children by cryomethodProceedings 10th World Congress of CryosurgeryMoscowRussiaDepartment Russian State University1998
  12. Tan SWallis R AHe YDavis PMast cells and hemangioma. Plast Reconstr Surg 2004; 113(3)9991011
  13. Waner MThe treatment of vascular lesions. Facial Plast Surg Clin North Am 1996; 4: 27581
  14. Waner MSuen JTreatment options for the management of hemangiomas: Hemangiomas and vascular malformations of the head and neckM WanerWiley-LissNew York 199923941
  15. Waner MSuen J YDinehart STreatment of hemangiomas of the head and neck. Laryngoscope 1992; 102: 112332 .
     How to Cite This Article :  Dr Vikas kapoor, Dr Shalini kapoor, Dr Jiji John,Dr Manish Tiwari. Multiple capillary haemangiomas in 4 month  
    old-Glare at the rare. IJOMCR Volume 02 Issue 01Jan-Mar 2016 page 01-07  


For Downloading PDF   

Click Here