Death by Medication; Nimesulide Induced Stevens-Johnson Syndrome: A Case Report. Nimesulide Induced Stevens-Johnson Syndrome

Abstract

Nimesulide is a nonsteroidal anti-inflammatory medicine (NSAID) that has been linked to severe cutaneous adverse events, such as Toxic Epidermal Necrolysis (TEN), a more severe variant of Stevens-Johnson Syndrome (SJS). We report the case of a female patient, age 20, who got SJS not long after starting nimesulide medication for fever and headache. The patient's condition progressively worsened and within 72 hours, TEN was reached despite timely drug cessation and supportive care. The patient died from multi-organ failure despite receiving intensive care in a specialized burn unit, including wound care, fluid resuscitation, and systemic corticosteroids. This case underscores the potentially fatal consequences of Nimesulide-induced severe cutaneous adverse reactions and emphasizes the importance of early recognition, prompt withdrawal of the offending agent, and intensive supportive care in mitigating mortality associated with these conditions. Additionally, it highlights the need for heightened vigilance among healthcare providers regarding the potential risks of NSAIDs.